Biomarkers Specificity CgA, CgB, pancreastatin H PP, NSE, neurokinin, neurotensin I HCG-α, HCG-β L The chromogranin family and pancreatic polypeptide, neuron-specific enolase (NSE) and alpha HCG constitute general markers for…
Inappropriate hypergastrinemia – gastric pH <2 Gastrinoma/Zollinger-Ellison syndrome Helicobacter pylori antral predominate Retained gastric antrum Gastric outlet obstruction Short bowel syndrome Appropriate hypergastrinemia – associated with hypochlorhydria Pernicious anemia Chronic…
Fig. 16.1 (a, b) Microscopic appearances of ampullary somatostatinoma. Haematoxylin and eosin staining (left) and strongly positive immunostaining with somatostatin (right) (ANNALS IMAGE) Psammoma bodies (round collections of calcium that…
Location Within NETs (%) Within GEP-NETs Incidence SEER (/100,000) Incidence (% of primary site) 5-year OS (%) GEP-NETs 67 5.25 <2 75–82 Gastric 9–20 0.3 1 45–64 Small intestine 39–42…
Fig. 26.1 A 45-year-old man with small bowel neuroendocrine tumor, with left hepatectomy for liver metastasis. (a) Axial CT scan (arterial phase) shows new metastatic liver lesion in the remnant…
Gene Pancreatic NET (%) n = 48 Intestinal NET (%) n = 68 MEN-1 44 2 DAXX 25 0 ATRX 18 0 TSC2 9 0 PTEN 7 0 PIK3CA 1 2 VHL 0 2…
, Cenk Sokmensuer2 and Ece Esin3 (1) Department of Medical Oncology, Cancer Institute, Hacettepe University, Sihhiye, Ankara, Turkey (2) Department of Pathology, School of Medicine, Hacettepe University, Ankara, Turkey (3) Department of…
Radiopharmaceutical Administered activity Number of cycles Time interval between cycles (weeks) 90Y-DOTATATE/90Y-DOTATOC 3.7 GBq (100 mCi)/m2 2 10–12 90Y-DOTATATE/90Y-DOTATOC (another protocol) 2.78–4.44 GBq (75–120 mCi) 2–4 10–12 177Lu-DOTATATE/177Lu DOTATOC 5.55–7.4…
Organ involved Specific tumor (prevalence by 40 years) Clinical presentation MEN1 Parathyroid disease (95 %) Diffuse hyperplasia Symptoms related to hypercalcemia or hypercalciuria Adenoma, multiple NETs PNETs (30–80 %)…
© Springer-Verlag Berlin Heidelberg 2015Suayib Yalcin and Kjell Öberg (eds.)Neuroendocrine Tumours10.1007/978-3-662-45215-8_33 33. Societies and Guidelines for Neuroendocrine Tumors Kjell Öberg1 (1) Endocrine Oncology, Uppsala University Hospital, Uppsala, Sweden Kjell Öberg Email: kjell.oberg@medsci.uu.se 33.1 Historical Background…
