Fig. 10.1 iNSC functioning as a cell-replacement therapy and as a producer of regenerative therapeutics for stroke patients. a A patient who has an ischemic or hemorrhagic stroke (ischemic stroke…
Fig. 1.1 Depiction of the three therapeutic approaches to acute brain injury. (Note that devices also have potential from clot-retrieval devices to devices that stimulate the sphenopalatine ganglia to blood…
Fig. 4.1 Change in the strategy for stroke. a Treatment of cardiovascular factors and administration of antiplatelet/coagulant drugs significantly contribute to the prevention of stroke onset. b In addition to…
Author, reference Study design Stroke Cell dose Manipulation Mode of application Efficacy Adverse effects Safety test Autologous bone marrow mononuclear cells Suarez-Monteaqudo, 2009 [40] No control group Treatment, n = 5 1…
Fig. 7.1 Differentiation fate of transplanted human fetal-derived NSCs and their effects on behavioral recovery after stroke. a Human fetal-derived NSCs (human nuclear antigen (HuNu)-positive cells, red) survive and migrate…
Fig. 14.1 The therapeutic potential of mesenchymal stem cells (MSC)-secreted factors for treating stroke. Following administration, MSC migrate to the site of stroke in response to chemoattractants, where they release…
Time after injury Cell type Route of administration Reference 24 h Umbilical cord blood Intra-arterial [10] 24 h Umbilical cord blood Intraperitoneal [11] 24 h Umbilical cord blood [12] 24 h Dental pulp stem…
Hypoxia–ischemia Cytokines Trophic/growth factors Drugs/pharmacological agents Hypoxia (0.5 to 3% O2) IL-6 EPO, SDF-1 Minocycline/doxycycline Cobalt Autologous stroke serum Diazoxide EPO erythropoietin, SDF-1 stromal derived factor-1 Table 11.2 Hypoxic preconditioning…
10. Watanabe K, Bois FY, Zeise L. Interspecies extrapolation: a reexamination of acute toxicity data. Risk Anal. 1992;12:301–10.PubMed 11. Davidson IW, Parker JC, Beliles RP. Biological basis for extrapolation across…
© Springer International Publishing Switzerland 2015David C. Hess (ed.)Cell Therapy for Brain Injury10.1007/978-3-319-15063-5_5 5. Clinical Development of MultiStem® for Treatment of Injuries and Diseases of the Central Nervous System Utilization of an Adult Stem…
