Seizure Mechanisms and Vulnerability in the Developing Brain John W. Swann Tallie Z. Baram Frances E. Jensen Solomon L. Moshé Introduction Throughout life, continuing maturational and functional changes within the…
Epilepsy in Vitro: Electrophysiology and Computer Modeling John G. R. Jefferys Introduction Epileptic seizures and other kinds of epileptic activity are emergent phenomena from the interactions between cells organized into…
Genetic Models of Epilepsy Jeffrey L. Noebels Introduction The success of molecular genetic strategies in finding genes underlying human monogenic epilepsies has set the stage for a new generation of…
Animal Models of Acquired Epilepsies and Status Epilepticus Giuliano G. Avanzini David M. Treiman Jerome Engel Jr. Introduction In animals, epilepsies with focal seizures can be faithfully reproduced by various…
Synaptic Plasticity Christophe Bernard Introduction Cognitive tasks are associated with specific firing patterns of neurons.27,60 During learning and memory processes, a conditioning stimulus can trigger morphological and modifications at the…
Early Events in the Development of the Cerebral Cortex Volney L. Sheen Christopher A. Walsh Introduction There is an increasing awareness that many epileptic conditions, particularly in the pediatric age…
Development of Cortical Excitability Peter B. Crino Introduction In the human brain, cerebral cortical development spans approximately weeks 7 to 24 of gestation and proceeds from a primordial neural tube…
Basal Ganglia and Brainstem Anatomy and Physiology Karen Gale Mark Proctor Jana Velíšková Astrid Nehlig Introduction Seizure activity does not spread diffusely throughout the brain, but propagates along specific anatomic…
Thalamocortical Anatomy and Physiology Hal Blumenfeld Douglas A. Coulter Introduction The thalamus and the thalamocortical system participate intimately in the generation of generalized seizures and probably are involved in the…
Limbic Anatomy and Physiology Dan C. McIntyre Philip A. Schwartzkroin Introduction The concept of a “limbic lobe” was first put forth by Broca27 as a means of labeling the various…
