and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany 6.1 The Cerebral Cortex The cerebral cortex is the overarching superordinate structure of the…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany 8.1 The Amyloid Precursor Protein and the Abnormal Protein Aβ A clear indicator for…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany 9.1 NFT Stage III: Progression into the Basal Temporal Neocortex, Including Portions of the…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany 7.1 Stages 1a and 1b: Development of Inclusions in Axons and of Pretangle Material…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany 2.1 Sporadic AD Is a Proteinopathy Linked to the Development of Intraneuronal Inclusions of…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany 5.1 Stage a: The Appearance of Abnormal Tau in Axons of Coeruleus Projection Neurons…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany Brains obtained at autopsy—following precautions for handling tissue of prion diseases—are fixed by immersion…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany The protein tau is central to the pathological process underlying sporadic AD. It is…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany The present exposition of the AD-related pathological process rests upon some basic assumptions: (1)…
and Kelly Del Tredici1 (1) Zentrum f. Biomed. Forschung AG Klinische Neuroanatomie/Abteilung Neurologie, Universität Ulm, Ulm, Germany The pattern of lesions that slowly develops during the AD-process is more easily understood…
