Fronto-Temporal Dementia (FTD)
Examples of speech “We are looking for one hor….like we…are just saying…I should not have done…I didn’t realize it, like I say………. I used to be very ….. I had…
Amyotrophic Lateral Sclerosis
1. Speech 4 Normal speech 3 Detectable disturbance 2 Intelligible without repeating 1 Speech with non-verbal communication 0 Loss of useful speech 2. Salivation 4 Normal 3 Slight but definite…
Huntington’s Disease
Title Authors Scale description Functional Capacity Rating Scale Shoulsan and Fahn (1979) Measures functional capacity across 5 domains on a scale of 1–5 Unified Huntington’s Disease Rating Scale (UHDRS) Kieburtz…
Parkinson’s Disease
Fig. 6.1 (a) H&E staining of a substantia nigra neuron containing a Lewy body; (b) The core of each Lewy body stains more strongly for α(alpha)-synuclein than the characteristic halo…
Neuroinflammatory Disorders
Fig. 15.1 Global prevalence of multiple sclerosis- people per 100,000 with MS However, recent evidence suggests that this latitude gradient in MS incidence may be decreasing. This may be partly…
Palliative Care and End of Life Care
(1) Wisdom Hospice, Consultant in Palliative Medicine, High Bank, Rochester, UK (2) University of Kent, Kent, UK (3) Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Dublin, Ireland …
Dementia and Cerebrovascular Disease
(1) Department of Medical Gerontology, Trinity College, Dublin, Dublin, Ireland (2) Department of Medical Gerontology, Mercer’s Institute for Successful Ageing, St James’s Hospital, Dublin, Ireland (3) Medical Gerontology, Trinity College,…
Clinical Trials in Neurodegeneration
Fig. 16.1 Targeted drug development in neurodegenerative diseases Once identified, candidate compounds are optimized for selectivity and affinity using in vitro models. Subsequently, testing in laboratory animals that model a…
Managing Neuropsychiatric Symptoms of Neurodegenerative Diseases
Neurodegenerative Alzheimer disease Frontotemporal dementia Dementia with Lewy bodies Huntington disease Corticobasal degeneration Progressive supranuclear palsy Multisystem atrophy Argyrophilic brain disease Wilson disease Hallevorden–Spatz disease Mitochondial diseases Kuf disease Metachromatic…
Medical Mimics of Neurodegenerative Diseases
Cervical spine MRI in Hirayama-disease In neutral neck position Inferior cervical cord segmental atrophy Segmental cord flattening High signal in the anterior aspect of the lower cervical cord Loss of…
