Serotonin-Producing Tumor
Fig. 14.1 Serotonin-producing PanNETs show different architectural features including trabecular (a) or acinar (b) patterns of growths, and some cases can present marked stromal fibrosis (c). Although serotonin-producing PanNETs are…
Glucagonoma
Fig. 9.1 Cutaneous manifestations of necrolytic migratory erythema. Glossitis (a) may be associated with the cutaneous lesions (b). The lesions are erythematous and polycyclic. The skin biopsy (c) shows a…
Insulinoma
Fig. 8.1 Large pancreatic insulinoma with amyloid stroma (hematoxylin eosin saffron, original magnification ×120) Fig. 8.2 Higher magnification showing well-differentiated neuroendocrine cells, without mitotic figures (hematoxylin eosin saffron, original magnification…
Pancreatic Neuroendocrine Tumors Producing GHRH, GH, Ghrelin, PTH, or PTHrP
Year Research Investigators 1924 Isolation of PTH Collip 1944 Isolation of GH Li et al. 1982 Isolation of GHRH Guillemin et al./Rivier et al.a First report of functioning GHRH-producing PanNET…
Immunohistochemical Approach to the Diagnosis and Prognostic Evaluation of Pancreatic Neuroendocrine Neoplasms
Fig. 7.1 Immunohistochemical localization of islet cell hormones in normal islets. (a) Insulin localization in approximately 60–70 % of islet cells. (b) Glucagon localization in the periphery of the islets…
The Role of Nuclear Medicine in the Diagnosis of Pancreatic Neuroendocrine Neoplasms
Fig. 3.1 Comparison between 18F-FDG PET/CT and 68Ga-DOTANOC PET/CT in a patient with a nodule in the pancreatic tail incidentally detected at CT. 18F-FDG PET/CT showed no 18F-FDG uptake in…
Nonfunctioning Pancreatic Neuroendocrine Neoplasms (Including PP-Producing and Calcitonin-Producing Tumors)
Fig. 16.1 Clear cell (lipid-rich) variant of pancreatic neuroendocrine tumor in (a). Oncocytic variant of pancreatic nonfunctioning neuroendocrine tumor in (b) Among prognostically relevant histologic findings, there are vascular invasion…
Somatostatin-Producing Tumor
Fig. 10.1 Functioning somatostatinoma characterized by a trabecular architecture (a) and showing somatostatin (b) and calcitonin (c) immunoreactivity (H original magnification ×400; immunohistochemistry original magnification ×200) Fig. 10.2 Nonfunctioning somatostatin-producing…
Historical Background and Epidemiology
Fig. 1.1 (a) Paul Langerhans (1847–1888) in 1873 (© Bildarchiv Preußischer Kulturbesitz, Berlin, 1873, Photographer: Ruf und Dilger [85]) (b) Histological appearance of the islet of Langerhans (hematoxylin-eosin) In 1893,…
